An injectable liposome for sustained release of tanshinone IIA to the treatment of acute blunt muscle injury by augmenting autophagy and alleviating oxidative stress.

An injectable liposome for sustained release of tanshinone IIA to the treatment of acute blunt muscle injury by augmenting autophagy and alleviating oxidative stress.

Model: Acute blunt skeletal muscle injury in rats

Tanshinone IIA liposome increased vimentin and desmin expression, reduced MHCIIB and collagen-I, promoted autophagy-related proteins while lowering p62, suppressed TNF-alpha and IL-6, reduced malondialdehyde and increased superoxide dismutase activity after muscle injury.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.