THERAPY DOSSIER · th-6c01fc9808db

Tanshinone IIA liposome (injectable, sustained release)

Nutraceutical · Tanshinone IIA (diterpenoid from Salvia miltiorrhiza) liposomal formulation; ChEMBL returned only the sulfonate derivative (sodium tanshinone IIA sulfonate).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Tanshinone IIA (diterpenoid from Salvia miltiorrhiza) liposomal formulation; ChEMBL returned only the sulfonate derivative (sodium tanshinone IIA sulfonate).
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02524964 ↗PHASE4unknown

Sodium Tanshinone IIA Sulfonate on Left Ventricular Remodeling after STEMI/PCI

Left Ventricular Remodeling · Acute Myocardial Infarction

Enrolment: 60 · Results not recorded

NCT01452477 ↗NAunknown

Effect of Tanshinone on Hormonal and Metabolic Features in PCOS

Polycystic Ovary Syndrome

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32913497 ↗2020Reported benefit

An injectable liposome for sustained release of tanshinone IIA to the treatment of acute blunt muscle injury by augmenting autophagy and alleviating oxidative stress.

RatCrushLimb / muscle crushinjection

Model: Acute blunt skeletal muscle injury in rats

Tanshinone IIA liposome increased vimentin and desmin expression, reduced MHCIIB and collagen-I, promoted autophagy-related proteins while lowering p62, suppressed TNF-alpha and IL-6, reduced malondialdehyde and increased superoxide dismutase activity after muscle injury.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

Loading the evidence…