Functional recovery with histomorphometric analysis of nerves and muscles after combination treatment with erythropoietin and dexamethasone in acute peripheral nerve injury.
MouseCrushPeripheral-nerve crushC57BL/6JMalen = n = 7 per group for functional analysis (four groups); n =…IntraperitonealErythropoietin 100 micrograms/kg; dexamethasone 2 mg/kg; co…Started immediately after the crush injury
Model: Acute sciatic nerve crush injury of the right hind limb, created proximal to the trifurcation with diagonal jawed forceps applied for 30 seconds
Combination erythropoietin plus dexamethasone significantly improved the sciatic functional index at 3, 7, 14 and 28 days after injury, whereas single agents differed significantly from saline only at day 28 (day 28 values: saline -21.1 +/- 3.9; erythropoietin -10.9 +/- 2.5; dexamethasone -10.4 +/-…
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