Combined Drug Approach to Prevent Ischaemia-Reperfusion Injury During Transplantation of Livers (CAPITL) - includes human recombinant erythropoietin
Reperfusion Injury
Enrolment: 143 · Results not recorded
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Biologic · Erythropoietin receptor agonist (AGONIST; direct interaction)
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Reperfusion Injury
Enrolment: 143 · Results not recorded
Myocardial Ischemic Reperfusion Injury
Enrolment: 97 · Results not recorded
Ischemia-Reperfusion Injury · Myocardial Infarction
Enrolment: 12 · Results not recorded
Anemia · Renal Insufficiency, Chronic
Enrolment: 164 · Results not recorded
Anemia
Enrolment: 305 · Results not recorded
Blood Transfusion · Blood Transfusion, Autologous · Orthopedic Procedures · Orthopedic Surgery · Cardiovascular Surgical Procedures · Mammaplasty
Enrolment: 112 · Results not recorded
Myocardial Infarction
Enrolment: 80 · Results not recorded
Anemia · Chronic Kidney Disease · Chronic Renal Failure
Enrolment: 165 · Results not recorded
Stroke
Enrolment: 96 · Results not recorded
Anemia
Enrolment: 0 · Results not recorded
Anemia · Renal Insufficiency, Chronic
Enrolment: 126 · Results not recorded
Anemia · Endometrial Diseases
Enrolment: 14 · Results not recorded
Substance Abuse Problem
Enrolment: 35 · Results not recorded
Kidney Disease, Chronic
Enrolment: 748 · Results not recorded
HIV Infections · Cytopenias
Enrolment not recorded · Results not recorded
22 studies reported at therapy level; 36 evidence entries itemised.
Model: Bilateral renal pedicle occlusion for 50 min followed by 3 days of reperfusion
Each of erythropoietin, ischaemic preconditioning and N-acetylcysteine alone improved renal function, reduced tubular injury, lessened oxidative stress and lowered plasma TNF-alpha and IL-6 compared with untreated ischaemia/reperfusion. The triple combination gave significantly greater protection t…
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Model: Cervical sub-acute spinal cord compression
rhEPO reduced motor neuron apoptosis and inflammatory cytokines and improved locomotor function after cervical spinal cord compression, with sustained low-dose benefit.
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Model: closed head weight-drop TBI with acute lung injury
rhEPO ameliorated TBI-induced acute lung injury and upregulated the pulmonary Nrf2 cytoprotective pathway.
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Model: Acute sciatic nerve crush injury of the right hind limb, created proximal to the trifurcation with diagonal jawed forceps applied for 30 seconds
Combination erythropoietin plus dexamethasone significantly improved the sciatic functional index at 3, 7, 14 and 28 days after injury, whereas single agents differed significantly from saline only at day 28 (day 28 values: saline -21.1 +/- 3.9; erythropoietin -10.9 +/- 2.5; dexamethasone -10.4 +/-…
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Model: Crush syndrome-associated acute kidney injury induced by 50 per cent glycerol at 7.5 ml/kg
Recombinant human erythropoietin improved renal function and tissue damage, lowered proinflammatory cytokine production and macrophage infiltration, and downregulated TLR4 and NF-kappaB p65 expression in kidney and in myoglobin-stimulated macrophages.
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Model: Single sublethal dose of 7 Gy gamma total body irradiation
Erythropoietin improved 30-day survival, alleviated myelosuppression and pancytopenia, restored bone marrow and spleen cellularity and splenic function, reduced hepatotoxicity biomarkers and oxidative stress, and prevented hepatic and splenic apoptosis via alpha-7-nAChR-JAK-2/STAT-3-Nrf-2 signallin…
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Model: Rhabdomyolysis-induced acute kidney injury by intramuscular injection of 50% glycerol 10 ml/kg into the hind limbs
EPO improved renal function and histology, reduced tubular apoptosis and pro-inflammatory cytokines, decreased macrophage recruitment and shifted macrophages towards an M2 phenotype via Jak2/STAT3/STAT6.
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Model: Hyperoxia-induced preterm brain injury, 24 h of 80 percent oxygen from postnatal day 6
A single dose at hyperoxia onset improved object recognition and spatial memory from postnatal day 30 to day 90 and reversed downregulation of neuronal plasticity genes, but although acute oligodendrocyte death at P7 was reduced it did not prevent subsequent hypomyelination or long-term white matte…
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Model: Controlled cortical impact traumatic brain injury delivered at postnatal day 12 (infantile model)
Controlled cortical impact produced chronic gait deficits (p=0.033) that were reversed by erythropoietin treatment (p=0.022). Diffusion tensor MRI showed widespread abnormalities of fractional anisotropy and mean, axial and radial diffusivity in vehicle-treated injured rats, with mean, axial and ra…
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Model: Acute carbon monoxide poisoning induced brain injury
Erythropoietin suppressed the carbon monoxide induced upregulation of TLR4 and NF-kappaB and of TNF-alpha, IL-1beta and IL-6 in hippocampal tissue and reduced histological oedema and neuronal necrosis.
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Model: Controlled cortical impact traumatic brain injury
rhEPO treatment significantly reduced acute brain oedema on T2 weighted MRI after controlled cortical impact, with a concomitant reduction in cerebral AQP4 immunoexpression. No quantitative effect sizes were reported in the available abstract.
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Model: Seawater aspiration-induced acute lung injury
EPO pretreatment increased arterial partial oxygen tension and reduced lung histological injury scores after seawater aspiration. It also attenuated the seawater-induced increases in pulmonary NF-kappa B p65, inducible nitric oxide synthase, caspase-3, TNF-alpha, IL-1beta, myeloperoxidase activity…
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Model: Acute thoracic spinal cord compressive injury
Delayed rhEPO reduced apoptosis and inflammation, promoted myelin repair and improved functional recovery. The greatest locomotor and histopathological improvement and the best myelin protection occurred at 5,000 U/kg, while 3,000, 4,000 and 5,000 U/kg gave similar ultrastructural protection and si…
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Model: Laminectomy at T11 followed by spinal cord injury
Erythropoietin-treated rats showed significantly better functional recovery, higher manganese-enhanced MRI signal-to-noise ratio at the lesion epicentre, and fewer microglia and apoptotic cells.
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Model: Acoustic overstimulation with white noise at 100 dB sound pressure level for 3 hours causing cochlear injury
Saline-treated noise-exposed rats showed significant threshold shifts for click and 6 kHz stimuli immediately after noise, whereas erythropoietin-treated rats did not. Erythropoietin also reduced the number of apoptotic cells in the cochlea.
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Model: Thermal scald-burn injury inducing multiorgan dysfunction and acute lung injury
rhEPO given 5 min before scald burn significantly reduced markers of multiorgan dysfunction (liver, kidney, lung and serum cytokines). In lung it reduced histological signs of tissue injury, bronchoalveolar lavage inflammatory/injury markers, neutrophil chemotaxis and infiltration, GSK-3beta activa…
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Model: Laminectomy at T8-T9 with vascular clip compression of the spinal cord
rhEPO markedly upregulated Nrf2 pathway components and significantly reduced locomotor deficit, spinal cord oedema and apoptosis at 72 hours after injury.
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Model: Acute subdural haematoma induced by subdural infusion of 400 microlitres autologous venous blood, with surgical evacuation of the haematoma
Intravenous EPO at 200 and 2000 IU reduced lesion volume from 38.2 to 28.5 and 22.2 cubic millimetres and cortical 0.02 IU reduced it from 36.0 to 11.2 cubic millimetres, whereas the highest doses by either route enlarged lesions to 46.5 and 67.9 cubic millimetres and 20,000 IU raised intracranial…
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Model: Combined left soleus muscle crush (instrumented clamp over full muscle length) with ipsilateral sciatic nerve crush or sham manipulation
Combined muscle and nerve injury caused significant loss of muscle strength that recovered incompletely by 42 days. EPO treated rats had greater muscle strength at days 7 and 42, less pain, improved nerve conduction velocity and increased bromodeoxyuridine positive proliferating cells.
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Model: Contusive spinal cord injury
rhEPO treated rats showed better sensory and motor transmission through spared spinal pathways than saline controls, most prominent at relatively early times, with a parallel time course to improvement in BBB score.
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Model: Amikacin-induced nephropathy (1.2 g/kg intraperitoneally)
Blood urea nitrogen rose from 13.1 plus or minus 0.4 mg/dL in saline controls to 26.6 plus or minus 3.9 mg/dL with amikacin (p < 0.01) and was significantly improved to 15.9 plus or minus 0.9 mg/dL with erythropoietin pretreatment, with marked reduction in histological tubular necrosis.
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Model: Hypobaric hypoxia simulating an altitude of 8000 m (acute mountain sickness model of global cerebral hypoxia)
Better spatial learning was seen only in the group given erythropoietin together with an enriched environment; erythropoietin alone had no influence on spatial memory.
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