Rosiglitazone ameliorates radiation-induced intestinal inflammation in rats by inhibiting NLRP3 inflammasome and TNF-alpha production
RatRadiationSprague-DawleyMaleIntraperitoneal3 mg/kg body weightFirst dose 5 min after abdominal irradiation
Model: Abdominal irradiation (9 Gy caesium gamma, 2.5 Gy/min) inducing acute small intestinal injury
Rosiglitazone improved villus height and crypt counts and reduced inflammatory cell infiltration compared with irradiation alone, and lowered serum IL-1beta (15.71 versus 41.56 pg/ml) and TNF-alpha (32.43 versus 47.61 pg/ml) along with reduced caspase-1 and NLRP3 expression. Co-administration of mo…
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