Delayed metformin treatment improves functional recovery following traumatic brain injury via central AMPK-dependent brain tissue repair.
MouseTBICryogenicC57BL/6maleintraperitoneal20, 50 or 100 mg/kg/day (100 mg/kg/day effective)delayed post-injury, initiated at day 1, day 3 or day 5 after cTBI
Model: Cryogenic traumatic brain injury (cTBI)
Metformin 100 mg/kg/day given day 1-14, day 1-10 or day 3-10 improved motor functional recovery and reduced infarct volume, whereas day 1-2 or day 5-12 dosing did not; extending treatment from day 5 to 2 weeks (day 5-28) restored benefit, indicating a therapeutic window of at least 5 days. Benefit…
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