The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.
MouseSpinal cord injuryComplete transectionC57BL/6 wild type and hFoxJ1-CreERT::tdTomato transgenic on C57BL/6 backgroundboth male and femalen = 118 mice in total (100 wild type and 18 hFoxJ1-CreERT); pro…non-invasive transcutaneous magnetic stimulation with the coil in close contact with the back at the injury site, under 2% isoflurane10 Hz for 10 min per day, trains of 10 s stimulation follow…acute paradigm started day 1 after injury; chronic paradigm started 10 to 11 da…
Model: Laminectomy at T9-T11 with dura removal then complete spinal cord transection with a 25-gauge needle; dorsal funiculus transection sparing the central canal in transgenic mice
rTSMS reduced the fibrotic scar approximately 2-fold at day 15 and 4-fold at day 90, reduced the glial scar core, and reduced Iba1 positive inflammation nearly 3-fold. Demyelinated area fell approximately 4-fold and surviving neurons rose from a mean of 139 to 233 per section, with substantial BDA-…
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