Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome.
MouseRadiationNUDE (athymic nude, Janvier)malen = Survival dose ranging 15 to 31 per group; therapy survival…intravenous, via the retro-orbital sinus600 microgram total, given as three 200 microgram injection…first dose after irradiation; Methods state 6 h whereas the abstract states 3 h…
Model: Lethal whole-body irradiation with an Alphee medical accelerator; dose ranging at 15, 13, 12 and 10 Gy, with 10 Gy used for all therapy experiments, producing acute radiation syndrome with gastrointestinal injury
Extracellular vesicles, but not MSC, significantly delayed death after 10 Gy irradiation (log-rank p < 0.0001), reducing the instantaneous risk of death by 85% (hazard ratio 0.15) and delaying LD50 by 3.5 days. They prevented the radiation-induced rise in gut permeability (5.7 +/- 1.0 versus 9.1 +/…
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