THERAPY DOSSIER · th-e4d475fcbf87

Human mesenchymal stromal cell-derived extracellular vesicles

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07144241 ↗PHASE2not yet recruiting

Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) Therapy for Type 2 Diabetes Mellitus Patients

Type 2 Diabetes Mellitus

Enrolment: 50 · Results not recorded

NCT03384433 ↗PHASE1/PHASE2unknown

Safety and Efficacy of Allogenic Mesenchymal Stem Cells Derived Exosome on Disability of Patients With Acute Ischemic Stroke: a Randomized, Single-blind, Placebo-controlled, Phase 1, 2 Trial

Cerebrovascular Disorders

Enrolment: 5 · Results not recorded

NCT05813379 ↗PHASE1/PHASE2unknown

Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Anti Aging

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32854778 ↗2020Reported benefit

Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome.

MouseRadiationNUDE (athymic nude, Janvier)malen = Survival dose ranging 15 to 31 per group; therapy survival…intravenous, via the retro-orbital sinus600 microgram total, given as three 200 microgram injection…first dose after irradiation; Methods state 6 h whereas the abstract states 3 h…

Model: Lethal whole-body irradiation with an Alphee medical accelerator; dose ranging at 15, 13, 12 and 10 Gy, with 10 Gy used for all therapy experiments, producing acute radiation syndrome with gastrointestinal injury

Extracellular vesicles, but not MSC, significantly delayed death after 10 Gy irradiation (log-rank p < 0.0001), reducing the instantaneous risk of death by 85% (hazard ratio 0.15) and delaying LD50 by 3.5 days. They prevented the radiation-induced rise in gut permeability (5.7 +/- 1.0 versus 9.1 +/…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…