Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-kappaB signaling.

Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-kappaB signaling.

Model: Lipopolysaccharide-induced acute liver injury (sepsis model), with RAW264.7 macrophage cell model

Irisin reduced LPS-induced liver injury, transaminase release and inflammatory cytokine production, and inhibited NLRP3 inflammasome and NF-kappaB activation.

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