Study of Metformin Drug Effect on Fracture Healing and Its Correlation to Serum Irisin Myokine Level
Bone Fracture
Enrolment: 40 · Results not recorded
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Hormone
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Bone Fracture
Enrolment: 40 · Results not recorded
Periodontal Diseases · Gingivitis · Obesity
Enrolment: 122 · Results not recorded
Irisin · Diabetic Nephropathy
Enrolment: 90 · Results not recorded
Healthy Subjects
Enrolment: 122 · Results not recorded
Diabetic Nephropathies
Enrolment: 200 · Results not recorded
Liver Fat · Type 2 Diabetes
Enrolment: 15 · Results not recorded
Myocardial Infarction · Coronary Artery Disease
Enrolment: 116 · Results not recorded
Breast Cancer
Enrolment: 100 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Bilateral renal ischaemia-reperfusion: microaneurysm clamps on both renal pedicles for 45 minutes followed by reperfusion, with blood and kidney harvested 24 hours later. Sham operation without clamping. In vitro: HK-2 hypoxia 3 h (1% O2) then 3 h reoxygenation
Irisin pretreatment reduced serum creatinine, blood urea nitrogen, KIM-1 and tubular injury score, lowered inflammatory markers and adhesion molecules, reduced cleaved caspase-3 and TUNEL-positive apoptosis, and increased UCP2 and phospho-AMPK. Protection was lost with UCP2 knockdown or AMPK inhibi…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Lipopolysaccharide-induced acute liver injury (sepsis model), with RAW264.7 macrophage cell model
Irisin reduced LPS-induced liver injury, transaminase release and inflammatory cytokine production, and inhibited NLRP3 inflammasome and NF-kappaB activation.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.