PRECLINICAL PUBLICATION · 2020

Molecular mechanism of long-term neuroprotective effects of gradual flow restoration on cerebral ischemia reperfusion injury in MCAO rats.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 32807453 ↗2020Reported benefit

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleApplied at reperfusion; outcomes assessed after 3 and 7 days of reperfusion

Model: Middle cerebral artery occlusion with reperfusion

Gradual flow restoration reduced neurological deficit and infarct volume and inhibited REST expression in the infarcted cortex.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.