THERAPY DOSSIER · th-21da7de753e6

Gradual flow restoration during reperfusion

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02732080 ↗NAcompleted

Effect of gradual reperfusion on myocardial oedema and coronary microvascular integrity in primary PCI

ST-elevation Acute Myocardial Infarction

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32807453 ↗2020Reported benefit

Molecular mechanism of long-term neuroprotective effects of gradual flow restoration on cerebral ischemia reperfusion injury in MCAO rats.

RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleApplied at reperfusion; outcomes assessed after 3 and 7 days of reperfusion

Model: Middle cerebral artery occlusion with reperfusion

Gradual flow restoration reduced neurological deficit and infarct volume and inhibited REST expression in the infarcted cortex.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

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