Nuclear Heme Oxidase-1 Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis after Spinal Cord Injury.
RatSpinal cord injuryContusionn = n = 8 per group across 4 groupsIntraspinal injection into the T10 segment5 microlitres of Ad-GFP-HO-1C23 vector7 days before injury induction
Model: T10 spinal cord contusion by modified Allen's weight-drop method (20 g weight dropped from 30 mm)
Nuclear HO-1 overexpression improved locomotor recovery, reduced neuronal apoptosis and lowered endoplasmic reticulum stress markers compared with blank and empty vector controls.
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