THERAPY DOSSIER · th-0008ec9fc764

Adenoviral nuclear heme oxygenase-1 (Ad-GFP-HO-1C23)

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32802873 ↗2020Reported benefit

Nuclear Heme Oxidase-1 Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis after Spinal Cord Injury.

RatSpinal cord injuryContusionn = n = 8 per group across 4 groupsIntraspinal injection into the T10 segment5 microlitres of Ad-GFP-HO-1C23 vector7 days before injury induction

Model: T10 spinal cord contusion by modified Allen's weight-drop method (20 g weight dropped from 30 mm)

Nuclear HO-1 overexpression improved locomotor recovery, reduced neuronal apoptosis and lowered endoplasmic reticulum stress markers compared with blank and empty vector controls.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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