Inducible nitric oxide synthase is required for epidermal permeability barrier homeostasis in mice.
MouseWoundiNOS knockout mice on B6;129P2 background and wild-type controlsTopical2 mmol/L SNAP or 2 mmol/L NOC-18, 60 microlitres per applic…Applied for 3 days before barrier disruption
Model: Acute epidermal permeability barrier disruption by tape stripping
iNOS deletion delayed epidermal barrier recovery after tape stripping, and topical nitric oxide donors improved recovery kinetics and upregulated differentiation and lipid synthetic genes.
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