THERAPY DOSSIER · th-d7de76d239ee

Nitric oxide donors S-nitroso-N-acetylpenicillamine (SNAP) and NOC-18

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32794261 ↗2020Reported benefit

Inducible nitric oxide synthase is required for epidermal permeability barrier homeostasis in mice.

MouseWoundiNOS knockout mice on B6;129P2 background and wild-type controlsTopical2 mmol/L SNAP or 2 mmol/L NOC-18, 60 microlitres per applic…Applied for 3 days before barrier disruption

Model: Acute epidermal permeability barrier disruption by tape stripping

iNOS deletion delayed epidermal barrier recovery after tape stripping, and topical nitric oxide donors improved recovery kinetics and upregulated differentiation and lipid synthetic genes.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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