Maresin 1 resolves aged-associated macrophage inflammation to improve bone regeneration.
MouseFractureTibiaC57BL/6JEqual numbers of male and femaleIntraperitoneal5 micrograms/kgGiven either at the time of fracture surgery or 3 days after injury
Model: Tibial fracture with intramedullary pinning
Maresin 1 given 3 days after fracture decreased cartilage formation, increased bone deposition and improved structural stiffness and force to fracture in aged mice, whereas dosing at the time of injury had no effect.
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