Preclinical evidence 4
4 studies reported at therapy level; 4 evidence entries itemised.
MouseFractureTibiaC57BL/6JEqual numbers of male and femaleIntraperitoneal5 micrograms/kgGiven either at the time of fracture surgery or 3 days after injury
Model: Tibial fracture with intramedullary pinning
Maresin 1 given 3 days after fracture decreased cartilage formation, increased bone deposition and improved structural stiffness and force to fracture in aged mice, whereas dosing at the time of injury had no effect.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
MouseChemical/toxinC57BL/6MaleAdministered 30 min before the primary injection of caerulein, that is as pretr…
Model: Severe acute pancreatitis with related lung injury induced by a combination of caerulein and lipopolysaccharide
Maresin 1 pretreatment reduced serum amylase, lipase, TNF-alpha, IL-1beta and IL-6, lowered myeloperoxidase activity in pancreas and lung, increased serum IL-10, reduced pancreatic NF-kappaB activation and lessened the severity of pancreatic and lung injury.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
MouseFractureTibiaC57BL/6 and Ccr2/Cx3cr1 reporter knock-in miceMalen = 111 C57BL/6 mice and 54 Ccr2/Cx3cr1 knock-in mice (165 in t…Intraperitoneal100 ng per mouse (2 micrograms/mL in saline with 0.14% etha…Prophylactic, given before skin incision
Model: Open stabilised tibia fracture of the left hind leg under isoflurane anaesthesia, with a 0.38 mm intramedullary pin and osteotomy, as a model of perioperative neurocognitive disorder
Pre-operative Maresin 1 reduced systemic pro-inflammatory cytokines and raised IL-10, prevented surgery-induced glial activation, claudin-5 loss and CCR2-positive macrophage infiltration into the hippocampus, and significantly improved 72 h contextual fear conditioning memory, with no significant e…
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MouseSpinal cord injuryContusionFemaleAdministered after spinal cord injury; exact time points not stated in the retr…
Model: Spinal cord contusion injury in adult female mice; contusion force and vertebral level not stated in the retrieved text
Specialised proresolving mediator biosynthesis was not induced at the lesion site up to 2 weeks after contusion injury. Exogenous maresin 1 accelerated neutrophil clearance, reduced macrophage accumulation, lowered proinflammatory cytokines, silenced STAT and MAPK signalling and redirected macropha…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
