Acute administration of metformin prior to cardiac ischemia/reperfusion injury protects brain injury.
RatIschaemia-reperfusionCardiacWistarMalen = 50 rats total, 10 sham and 10 per treatment groupIntravenous via the femoral vein100, 200 or 400 mg/kg15 minutes before cardiac ischaemia
Model: Cardiac ischaemia-reperfusion injury, 30 minutes of cardiac ischaemia followed by 120 minutes of reperfusion, with assessment of secondary brain damage
All three metformin doses improved brain mitochondrial function, reduced microglial hyperactivation, amyloid beta and tau phosphorylation and preserved dendritic spine density after cardiac ischaemia-reperfusion.
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