Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model.
MouseRadiationBALB/cFemaleTopical (applied to the irradiated, depilated skin area)0.05% and 0.5% (w/v) phlorotannins dissolved in sesame oilStarted on the day of irradiation
Model: X-ray irradiation of the right hind leg skin (6 MV, 12 Gy per fraction on three consecutive days, total 36 Gy, dose rate 3.96 Gy per minute) to induce radiation dermatitis
Topical phlorotannins lowered peak and day 21 radiation dermatitis scores versus vehicle (p < 0.001) and reduced irradiation-induced epidermal thickening (from 181.8 micrometres to 118.5 and 95.40 micrometres at day 14 with 0.05% and 0.5%) and dermal thickening (from 307.8 micrometres to 203.1 and…
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