THERAPY DOSSIER · th-07d2671c2b16

Phlorotannins from brown seaweed (ethanolic extract), applied topically in sesame oil

Nutraceutical · Phlorotannin polyphenols from brown seaweed (ethanolic extract).

Evidence & regulatory context

Mechanism: Phlorotannin polyphenols from brown seaweed (ethanolic extract).
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04141241 ↗PHASE2completed

Ecklonia cava Phlorotannin (PH100) in T2DM With Cardiovascular Complications

Type 2 Diabetes Mellitus

Enrolment: 82 · Results not recorded

NCT04335045 ↗PHASE1completed

Safety and PK of PH100 (Phlorotannin) Capsules in Healthy Volunteers

Safety Issues

Enrolment: 48 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32707897 ↗2020Reported benefit

Topical Application of Phlorotannins from Brown Seaweed Mitigates Radiation Dermatitis in a Mouse Model.

MouseRadiationBALB/cFemaleTopical (applied to the irradiated, depilated skin area)0.05% and 0.5% (w/v) phlorotannins dissolved in sesame oilStarted on the day of irradiation

Model: X-ray irradiation of the right hind leg skin (6 MV, 12 Gy per fraction on three consecutive days, total 36 Gy, dose rate 3.96 Gy per minute) to induce radiation dermatitis

Topical phlorotannins lowered peak and day 21 radiation dermatitis scores versus vehicle (p < 0.001) and reduced irradiation-induced epidermal thickening (from 181.8 micrometres to 118.5 and 95.40 micrometres at day 14 with 0.05% and 0.5%) and dermal thickening (from 307.8 micrometres to 203.1 and…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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