Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock-resuscitation-induced acute lung injury through inhibiting the NLRP3 inflammasome.
RatHaemorrhage/shockControlledSprague-Dawleymalen = 40 rats in total, 10 per group (4 groups)intraperitoneal5 micrograms per kg per hour, administered over 30 minImmediately after blunt chest trauma (or sham surgery)
Model: Blunt chest trauma (2.45 J bilateral chest impact) followed by controlled haemorrhagic shock (mean arterial pressure 35-45 mmHg maintained 1 h) and resuscitation with shed blood plus Ringer's lactate (1:1) over 1 h
Dexmedetomidine improved oxygenation, reduced lung wet/dry ratio and histological injury score, lowered MDA, LDH and MPO and proinflammatory cytokines, and reduced NLRP3, ASC and caspase-1 expression relative to the untreated injury group.
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