Glaucoma after Ocular Surgery or Trauma: The Role of Infiltrating Monocytes and Their Response to Cytokine Inhibitors.
MouseOtherPrompt administration after ocular injury
Model: Three ocular injury models: corneal suture, penetrating keratoplasty, and globe injury, with monocyte fate mapping
Ocular surgery or trauma caused robust monocyte infiltration into the retina with upregulation of Tnf, Il1b and Il6 within 24 hours, accompanied by ganglion cell apoptosis. Prompt inhibition of TNF-alpha or IL-1beta markedly suppressed monocyte infiltration and ganglion cell loss.
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