Combining a CD40L-binding protein (VIB4920) with a TNF-alpha inhibitor for inadequately controlled rheumatoid arthritis
Rheumatoid Arthritis
Enrolment: 2 · Results not recorded
Loading the evidence…
Biologic · Drug-class entry, no specific agent named in the source abstract, so no ChEMBL resolution attempted. Trials listed are class-level TNF-alpha inhibitor studies (infliximab, adalimumab, epidural TNFi) and are indirect evidence of clinical translation for the class, not for a named agent. FLAGGED for manual review.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Rheumatoid Arthritis
Enrolment: 2 · Results not recorded
Chronic Granulomatous Disease · Crohn's-like IBD
Enrolment: 40 · Results not recorded
Mucopolysaccharidosis Type I · Type II · Type VI
Enrolment: 2 · Results not recorded
Spinal Stenosis
Enrolment: 90 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Three ocular injury models: corneal suture, penetrating keratoplasty, and globe injury, with monocyte fate mapping
Ocular surgery or trauma caused robust monocyte infiltration into the retina with upregulation of Tnf, Il1b and Il6 within 24 hours, accompanied by ganglion cell apoptosis. Prompt inhibition of TNF-alpha or IL-1beta markedly suppressed monocyte infiltration and ganglion cell loss.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.