Oxidative stress activates the TRPM2-Ca-NLRP3 axis to promote PM-induced lung injury of mice.

Oxidative stress activates the TRPM2-Ca-NLRP3 axis to promote PM-induced lung injury of mice.

Model: Particulate matter (PM2.5) exposure-induced acute lung injury, with parallel in vitro work in A549 cells and primary rat type II alveolar epithelial cells

N-acetyl-L-cysteine attenuated inflammatory cell accumulation, alveolar wall thickening and the degree of PM2.5-induced lung injury in vivo, and reactive oxygen species were shown to regulate intracellular calcium, TRPM2 and NLRP3 expression, supporting a ROS-TRPM2-calcium-NLRP3 pathway.

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