Enoxaparin Attenuates Acute Lung Injury and Inflammasome Activation after Traumatic Brain Injury.
MouseTBIUnspecifiedC57BL/6Male1 mg/kg30 minutes after injury
Model: Severe traumatic brain injury model with secondary acute lung injury
Severe traumatic brain injury increased caspase-1 and IL-1beta in brain and lung at 24 hours. Enoxaparin attenuated inflammasome protein expression in both organs and significantly decreased the acute lung injury score and neutrophil and macrophage infiltration.
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