PRECLINICAL PUBLICATION · 2020

Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing.

Rat / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Hybrid hydrogel of aminated fish scale collagen and oxidised sodium alginate loaded with the antimicrobial peptides polymyxin B sulfate and bacitracin, cross-linked by a Schiff base reaction

PMID 32668308 ↗2020Reported benefit

Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing.

RatWoundTopical application to the wound

Model: Acute full-thickness excisional skin wound in a rat model

The hybrid hydrogel was effective against Escherichia coli and Staphylococcus aureus, promoted cell growth and angiogenesis in vitro, and promoted full-thickness wound healing in rats by accelerating re-epithelialisation, collagen deposition and angiogenesis.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.