THERAPY DOSSIER · th-e77115e7d907

Hybrid hydrogel of aminated fish scale collagen and oxidised sodium alginate loaded with the antimicrobial peptides polymyxin B sulfate and bacitracin, cross-linked by a Schiff base reaction

Device · Aminated fish-scale collagen/oxidised alginate Schiff-base hydrogel loaded with polymyxin B and bacitracin; biomaterial construct.

Device Suggest a correction

Evidence & regulatory context

Mechanism: Aminated fish-scale collagen/oxidised alginate Schiff-base hydrogel loaded with polymyxin B and bacitracin; biomaterial construct.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32668308 ↗2020Reported benefit

Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing.

RatWoundTopical application to the wound

Model: Acute full-thickness excisional skin wound in a rat model

The hybrid hydrogel was effective against Escherichia coli and Staphylococcus aureus, promoted cell growth and angiogenesis in vitro, and promoted full-thickness wound healing in rats by accelerating re-epithelialisation, collagen deposition and angiogenesis.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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