Photodynamic Therapy Delays Cutaneous Wound Healing in Mice.
MouseWoundC57BL/6JTopical application of MAL to the wound followed by red light irradiationMAL applied after wounding, with red light delivered after 1 to 3 hours of incu…
Model: Two excisional cutaneous wounds, one either side of the midline, healing by secondary intention
No difference was seen during the first week, but at week 2 photodynamic therapy delayed re-epithelialisation, with epithelium partially absent from the wound bed at day 14, thicker dermis with more collagen fibres and inflammatory cells, significantly fewer CD31 blood vessels and greater collagen…
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