Trial title not recorded
Actinic Keratosis
Enrolment: 9 · Results not recorded
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Procedure · Prodrug converted intracellularly to protoporphyrin IX; on red-light irradiation generates singlet oxygen causing DNA damage and cell death. ChEMBL mechanism record 'DNA inhibitor', mechanism comment 'Photodynamic therapy'. Salt form CHEMBL1201093 (hydrochloride, Metvixia) is the dosed ingredient. ATC L01XD03.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Actinic Keratosis
Enrolment: 9 · Results not recorded
Actinic Keratoses
Enrolment: 557 · Results not recorded
Basal Cell Carcinoma
Enrolment: 281 · Results not recorded
Actinic Keratosis · Basal Cell Carcinoma · Bowen's Disease · Squamous Cell Carcinoma · Warts
Enrolment: 82 · Results not recorded
Actinic Keratoses
Enrolment: 100 · Results not recorded
Basal Cell Carcinoma
Enrolment not recorded · Results not recorded
Nodular Basal Cell Carcinoma
Enrolment: 34 · Results not recorded
Microinvasive Squamous Cell Carcinoma
Enrolment: 45 · Results not recorded
Actinic Keratosis
Enrolment: 45 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Two excisional cutaneous wounds, one either side of the midline, healing by secondary intention
No difference was seen during the first week, but at week 2 photodynamic therapy delayed re-epithelialisation, with epithelium partially absent from the wound bed at day 14, thicker dermis with more collagen fibres and inflammatory cells, significantly fewer CD31 blood vessels and greater collagen…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.