A Combination of Kidney Ischemia and Injection of Isolated Mitochondria Leads to Activation of Inflammation and Increase in Mortality Rate in Rats.
RatIschaemia-reperfusionRenalMale
Model: Renal ischaemia/reperfusion combined with simultaneous systemic (intraperitoneal) administration of isolated mitochondria
Intraperitoneal injection of isolated mitochondria produced circulating mitochondrial DNA and proinflammatory changes, and combining this with renal ischaemia/reperfusion sharply increased mortality. Treatment with a mitochondria-targeted antioxidant increased survival, implicating mitochondrial re…
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