THERAPY DOSSIER · th-1f540f9903cc

Mitochondria-targeted antioxidant

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01167088 ↗PHASE2terminated

MitoQ 40 mg versus placebo for raised liver enzymes due to non-alcoholic fatty liver disease

Non-alcoholic Fatty Liver Disease

Enrolment: 110 · Results not recorded

NCT02597023 ↗NAcompleted

Oral mitoquinone (MitoQ) supplementation for improving physiological function in middle-aged and older adults

Aging

Enrolment: 55 · Results not recorded

NCT05872139 ↗NAcompleted

Exercise/cardiorespiratory fitness and endothelial function with ageing: role of mitochondrial-derived oxidative stress (mitoquinone mesylate)

Aging · Endothelial Dysfunction

Enrolment: 23 · Results not recorded

NCT07229261 ↗NArecruiting

MitoQ (mitoquinol mesylate) to ameliorate vascular function in preeclampsia

Preeclampsia · Pregnancy

Enrolment: 80 · Results not recorded

NCT07406243 ↗NAnot yet recruiting

Mitochondrial-targeted antioxidant supplementation for cerebrovascular function in postmenopausal women

Aging · Postmenopause

Enrolment: 86 · Results not recorded

NCT03514875 ↗NAwithdrawn

Mitochondrial-targeted antioxidant on carotid endothelial function and brain blood flow in mild cognitive impairment

Mild Cognitive Impairment · Alzheimer Disease, Early Onset

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32651821 ↗2020Reported benefit

A Combination of Kidney Ischemia and Injection of Isolated Mitochondria Leads to Activation of Inflammation and Increase in Mortality Rate in Rats.

RatIschaemia-reperfusionRenalMale

Model: Renal ischaemia/reperfusion combined with simultaneous systemic (intraperitoneal) administration of isolated mitochondria

Intraperitoneal injection of isolated mitochondria produced circulating mitochondrial DNA and proinflammatory changes, and combining this with renal ischaemia/reperfusion sharply increased mortality. Treatment with a mitochondria-targeted antioxidant increased survival, implicating mitochondrial re…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.

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