Enolase inhibition alters metabolic hormones and inflammatory factors to promote neuroprotection in spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyMalen = n = 3-8 per group (immunohistochemistry n = 3-6)Intravenous (tail vein)100 microg/kg in 100 microLFirst dose 15 min after injury
Model: T10 contusion spinal cord injury by the Perot weight-drop method, 5 g weight dropped from 8 cm onto a 0.3 cm impounder after T10 laminectomy under ketamine 80 mg/kg plus xylazine 10 mg/kg anaesthesia
Prolonged ENOblock administration attenuated injury-induced increases in vimentin, Cox-2 and caspase-1 at the lesion and reduced microglial and astrocytic activation. Neuroprotection was evident as recovery of neurofilament protein, increased NeuN and MBP, and reduced chondroitin sulfate proteoglyc…
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