Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatSpinal cord injuryContusionSprague-DawleyMalen = n = 3-8 per group (immunohistochemistry n = 3-6)Intravenous (tail vein)100 microg/kg in 100 microLFirst dose 15 min after injury
Model: T10 contusion spinal cord injury by the Perot weight-drop method, 5 g weight dropped from 8 cm onto a 0.3 cm impounder after T10 laminectomy under ketamine 80 mg/kg plus xylazine 10 mg/kg anaesthesia
Prolonged ENOblock administration attenuated injury-induced increases in vimentin, Cox-2 and caspase-1 at the lesion and reduced microglial and astrocytic activation. Neuroprotection was evident as recovery of neurofilament protein, increased NeuN and MBP, and reduced chondroitin sulfate proteoglyc…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
RatSpinal cord injuryContusionSprague-DawleyMaleIntravenous injection100 micrograms/kg in 100 microlitres15 minutes and 24 hours after injury
Model: Acute contusion spinal cord injury after T10 laminectomy, weight dropped from a height of 8 cm onto a 0.3 cm diameter impounder on the exposed cord, under ketamine 80 mg/kg and xylazine 10 mg/kg anaesthesia
ENOblock significantly lowered serum neuron specific enolase and inflammatory cytokines and chemokines, altered metabolic factors and MMP expression in cord tissue, and reduced gliosis on immunohistochemistry.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
