Effects of Percutaneous Collagen Induction Therapy Associated with Hyaluronic Acid on Inflammatory Response, Oxidative Stress, and Collagen Production.
RatWoundWistarMalen = 36 adult Wistar rats in 6 groups (n = 6 per group)Topical/percutaneousHyaluronic acid 0.9%; microneedling at 0.5 mm and 1.0 mm ne…Applied at the time of the procedure
Model: Percutaneous collagen induction (microneedling) microlesions of skin using 0.5 mm or 1.0 mm needle length under anaesthesia after trichotomy
Combining percutaneous collagen induction with hyaluronic acid lowered TNF-alpha relative to control and to percutaneous collagen induction alone, while significantly increasing anti-inflammatory cytokines and growth factors. Oxidant and oxidative damage markers fell and antioxidant defence rose in…
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