THERAPY DOSSIER · th-d99a351b7577

Percutaneous collagen induction (microneedling) combined with hyaluronic acid 0.9%

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07317856 ↗NAnot yet recruiting

Microneedling with hyaluronic acid injection for gingival augmentation in thin gingival phenotype

Thin Gingival Biotype

Enrolment: 20 · Results not recorded

NCT05869136 ↗NAunknown

Microneedling alone vs microneedling with hyaluronic acid in thin gingival phenotype

Thin-gingiva

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32647956 ↗2020Reported benefit

Effects of Percutaneous Collagen Induction Therapy Associated with Hyaluronic Acid on Inflammatory Response, Oxidative Stress, and Collagen Production.

RatWoundWistarMalen = 36 adult Wistar rats in 6 groups (n = 6 per group)Topical/percutaneousHyaluronic acid 0.9%; microneedling at 0.5 mm and 1.0 mm ne…Applied at the time of the procedure

Model: Percutaneous collagen induction (microneedling) microlesions of skin using 0.5 mm or 1.0 mm needle length under anaesthesia after trichotomy

Combining percutaneous collagen induction with hyaluronic acid lowered TNF-alpha relative to control and to percutaneous collagen induction alone, while significantly increasing anti-inflammatory cytokines and growth factors. Oxidant and oxidative damage markers fell and antioxidant defence rose in…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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