Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-kappaB and VEGF.
MouseRadiationC57BL/6 (methods also refer to wild-type SPF mice)Male and femalen = 120 mice in 6 groups, 20 per group, with 10 per group sacri…Intrarectal enema, retained for 5 min1800, 3600 and 7200 mg/kgStarted on the second day after irradiation
Model: Acute radiation proctitis induced by pelvic local irradiation with 27 Gy at 400 cGy/min using 6 MV X-rays from a linear accelerator
Changrui enema lowered the general signs score and rectal pathological grade in irradiated mice and restored body weight, with the high dose outperforming dexamethasone plus gentamicin on general signs. It reduced irradiation-induced IL-1beta, NF-kappaB, VEGF, AQP1 and p-ERK1/2 and increased AQP3 a…
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