THERAPY DOSSIER · th-76993e42ac80

Changrui enema (herbal prescription containing Sanguisorba officinalis, Agrimonia pilosa, Panax pseudoginseng, Bletilla striata, Colla corii asini, Rheum officinale and Acacia catechu)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32638843 ↗2020Reported benefit

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-kappaB and VEGF.

MouseRadiationC57BL/6 (methods also refer to wild-type SPF mice)Male and femalen = 120 mice in 6 groups, 20 per group, with 10 per group sacri…Intrarectal enema, retained for 5 min1800, 3600 and 7200 mg/kgStarted on the second day after irradiation

Model: Acute radiation proctitis induced by pelvic local irradiation with 27 Gy at 400 cGy/min using 6 MV X-rays from a linear accelerator

Changrui enema lowered the general signs score and rectal pathological grade in irradiated mice and restored body weight, with the high dose outperforming dexamethasone plus gentamicin on general signs. It reduced irradiation-induced IL-1beta, NF-kappaB, VEGF, AQP1 and p-ERK1/2 and increased AQP3 a…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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