Reproducible Large-Scale Isolation of Exosomes from Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Application in Acute Kidney Injury.
RatChemical/toxinSprague-DawleyMaleIntravenous (tail vein) at 1 mL/minTwo particle doses corresponding to 21 and 70 microgram of…8 h after cisplatin injection
Model: Lethal acute kidney injury induced by a single intraperitoneal injection of cisplatin 10 mg/kg in saline
Cisplatin caused deaths from day 5, with 80% mortality in the vehicle group, while exosome treatment raised survival to up to 50%. Exosome treatment also slowed body weight loss, and repeated high-dose administration restored weight to near that of uninduced controls. Blood urea nitrogen and serum…
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