THERAPY DOSSIER · th-d72a256200fa

ASC-exosomes, exosomes from human adipose tissue-derived mesenchymal stem/stromal cells isolated by tangential flow filtration

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07183384 ↗Injury indicationPHASE1/PHASE2recruiting

Mesenchymal stem cell-derived exosome therapy for endothelial dysfunction in postpartum mothers with prior preeclampsia

Preeclampsia · Endothelial Injury

Enrolment: 80 · Results not recorded

NCT04388982 ↗PHASE1/PHASE2unknown

Exosomes from allogenic adipose mesenchymal stem cells in mild to moderate Alzheimer's dementia

Alzheimer Disease

Enrolment: 9 · Results not recorded

NCT04544215 ↗PHASE1/PHASE2suspended

Allogeneic human adipose-derived mesenchymal progenitor cell exosomes nebuliser for carbapenem-resistant Gram-negative pulmonary infection

Drug-resistant infection

Enrolment: 60 · Results not recorded

NCT04276987 ↗PHASE1completed

Aerosol inhalation of exosomes derived from allogenic adipose mesenchymal stem cells in severe COVID-19 pneumonia

Coronavirus

Enrolment: 24 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32635660 ↗2020Reported benefit

Reproducible Large-Scale Isolation of Exosomes from Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Application in Acute Kidney Injury.

RatChemical/toxinSprague-DawleyMaleIntravenous (tail vein) at 1 mL/minTwo particle doses corresponding to 21 and 70 microgram of…8 h after cisplatin injection

Model: Lethal acute kidney injury induced by a single intraperitoneal injection of cisplatin 10 mg/kg in saline

Cisplatin caused deaths from day 5, with 80% mortality in the vehicle group, while exosome treatment raised survival to up to 50%. Exosome treatment also slowed body weight loss, and repeated high-dose administration restored weight to near that of uninduced controls. Blood urea nitrogen and serum…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

Loading the evidence…