The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice.
MouseChemical/toxinC57Bl/6JMaleIntraperitoneal1 mg/kg or 2 mg/kg in 0.1 mL sterile saline prepared from a…Starting 24 h after nitrogen mustard instillation
Model: Single intratracheal instillation of mechlorethamine hydrochloride (nitrogen mustard) 0.625 mg/kg at 2 microlitre/g body weight under xylazine 6 mg/kg plus ketamine 60 mg/kg anaesthesia; controls received sterile saline by the same route
AUY-922 reduced nitrogen mustard-induced weight loss and markedly lowered bronchoalveolar lavage white blood cell counts and total protein at both 10 and 30 days. Histology showed preserved parenchymal architecture and lower Ashcroft scores, with reduced collagen type I, elastin and fibronectin and…
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