A Phase II Open-Label Trial of AUY922, an HSP90 Inhibitor, in Patients With ALK-Rearranged Advanced NSCLC and Acquired Resistance to Prior ALK TKI
Non Small Cell Lung Cancer
Enrolment: 6 · Results not recorded
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Drug · INHIBITOR of heat shock protein HSP90 (direct interaction, disease efficacy).
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Non Small Cell Lung Cancer
Enrolment: 6 · Results not recorded
Lymphoma
Enrolment: 21 · Results not recorded
Advanced Gastric Cancer · Gastro-esophageal Junction Cancer
Enrolment: 68 · Results not recorded
Adenocarcinoma of the Pancreas · Metastatic Disease
Enrolment: 15 · Results not recorded
Breast Cancer · Hematologic Neoplasms
Enrolment: 117 · Results not recorded
Advanced HER2-positive Breast Cancer
Enrolment: 45 · Results not recorded
Breast Cancer · Metastatic Breast Cancer
Enrolment: 0 · Results not recorded
Advanced Solid Tumors
Enrolment: 37 · Results not recorded
Unspecified Adult Solid Tumor
Enrolment: 2 · Results not recorded
Breast Cancer
Enrolment: 7 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Single intratracheal instillation of mechlorethamine hydrochloride (nitrogen mustard) 0.625 mg/kg at 2 microlitre/g body weight under xylazine 6 mg/kg plus ketamine 60 mg/kg anaesthesia; controls received sterile saline by the same route
AUY-922 reduced nitrogen mustard-induced weight loss and markedly lowered bronchoalveolar lavage white blood cell counts and total protein at both 10 and 30 days. Histology showed preserved parenchymal architecture and lower Ashcroft scores, with reduced collagen type I, elastin and fibronectin and…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Intratracheal instillation of 0.1 N hydrochloric acid, 2 microlitre/g body weight, at day 0
AUY-922 started 24 h after acid exposure suppressed sustained inflammation, inhibited profibrotic ERK and HSP90 activation, improved lung function and markedly reduced extracellular matrix accumulation and histological fibrosis.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.