Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats.
RatChemical/toxinSprague-DawleyMalen = n = 6 per group for histology and lung injury score; n = 3…Intragastric (oral gavage)16, 8 and 4 g/kg crude drug at 1 mL/100 g body weightBeginning 2 h after the last PM2.5 instillation
Model: Acute lung injury induced by intratracheal instillation of PM2.5 suspension (10 mg/mL) at 0.1 mL/100 g body weight under 3% isoflurane anaesthesia, repeated on days 1, 3, 5 and 7
Ma xing shi gan decoction at 16 and 8 g/kg significantly reduced PM2.5-induced histopathological change and lung injury scores and lowered the proportion of TUNEL-positive cells. Cytochrome c and cleaved caspase-3 were suppressed, Bax fell and Bcl-2 rose, indicating a dose-dependent anti-apoptotic…
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