THERAPY DOSSIER · th-1f3cdb85bb70

Ma xing shi gan decoction (Ephedra Herb 4 g, Bitter Almond 12 g, Gypsum 24 g, Liquorice Root 8 g; crude drug 2 g/mL)

Nutraceutical · Ma Xing Shi Gan decoction, a four-herb traditional Chinese formula.

Evidence & regulatory context

Mechanism: Ma Xing Shi Gan decoction, a four-herb traditional Chinese formula.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32627816 ↗2020Reported benefit

Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats.

RatChemical/toxinSprague-DawleyMalen = n = 6 per group for histology and lung injury score; n = 3…Intragastric (oral gavage)16, 8 and 4 g/kg crude drug at 1 mL/100 g body weightBeginning 2 h after the last PM2.5 instillation

Model: Acute lung injury induced by intratracheal instillation of PM2.5 suspension (10 mg/mL) at 0.1 mL/100 g body weight under 3% isoflurane anaesthesia, repeated on days 1, 3, 5 and 7

Ma xing shi gan decoction at 16 and 8 g/kg significantly reduced PM2.5-induced histopathological change and lung injury scores and lowered the proportion of TUNEL-positive cells. Cytochrome c and cleaved caspase-3 were suppressed, Bax fell and Bcl-2 rose, indicating a dose-dependent anti-apoptotic…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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