Effects of sacral nerve electrical stimulation on 5-HT and 5-HT3AR/5-HT4R levels in the colon and sacral cord of acute spinal cord injury rat models.
RatSpinal cord injuryContusionSprague-Dawley, specific pathogen-free gradeFemalen = 70 rats purchased; 20 sham, 50 underwent injury with 4 deat…Transcutaneous needle electrodes at bilateral S3 sacral foraminaPulse width 0.2 ms, frequency 10 Hz, stimulation duration 1…Commenced 24 h after successful modelling, on day 2
Model: Acute severe contusion spinal cord injury at T11-T12 using a 10 g weight dropped from 60 mm with the New York University Impactor after laminectomy
Sacral nerve stimulation increased faecal output, shortened time to first faecal passage, improved faecal texture and colon histology, and raised 5-HT with upregulated 5-HT3AR and 5-HT4R mRNA and protein in colon and spinal cord.
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