THERAPY DOSSIER · th-cbd4b1be95f3

Sacral nerve electrical stimulation at bilateral S3 neural foramina

Procedure · Neuromodulation procedure/device; no ChEMBL entity by nature. Trials retained are sacral-root or sacral-surface stimulation studies only; tibial and pudendal nerve stimulation hits from the keyword search were excluded as off-target.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Neuromodulation procedure/device; no ChEMBL entity by nature. Trials retained are sacral-root or sacral-surface stimulation studies only; tibial and pudendal nerve stimulation hits from the keyword search were excluded as off-target.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05214378 ↗Injury indicationEARLY_PHASE1completed

High frequency sacral root stimulation (Finetech-Brindley system) to improve bladder and bowel emptying following spinal cord injury

Spinal Cord Injury

Enrolment: 4 · Results not recorded

NCT00200005 ↗PHASE4completed

Sacral nerve stimulation (InterStim implantable neurostimulator) for anal incontinence and bowel control

Faecal Incontinence · Constipation

Enrolment: 140 · Results not recorded

NCT00282490 ↗NAcompleted

Sacral transcutaneous nerve stimulation for functional daytime incontinence in children with overactive bladder

Overactive Bladder · Urinary Incontinence

Enrolment: 30 · Results not recorded

NCT02600676 ↗NAcompleted

Sacral transcutaneous electrical nerve stimulation in children with enuresis

Enuresis · Urinary Incontinence

Enrolment: 52 · Results not recorded

NCT01313026 ↗NAterminated

Low anterior resection syndrome treated by percutaneous nerve evaluation (sacral) and transanal irrigation

Rectal Cancer

Enrolment: 14 · Results not recorded

NCT06156995 ↗NAunknown

Deep acupuncture at Zhongliao point stimulating the sacral nerve for colonic slow transit constipation

Constipation

Enrolment: 70 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32626986 ↗2020Reported benefit

Effects of sacral nerve electrical stimulation on 5-HT and 5-HT3AR/5-HT4R levels in the colon and sacral cord of acute spinal cord injury rat models.

RatSpinal cord injuryContusionSprague-Dawley, specific pathogen-free gradeFemalen = 70 rats purchased; 20 sham, 50 underwent injury with 4 deat…Transcutaneous needle electrodes at bilateral S3 sacral foraminaPulse width 0.2 ms, frequency 10 Hz, stimulation duration 1…Commenced 24 h after successful modelling, on day 2

Model: Acute severe contusion spinal cord injury at T11-T12 using a 10 g weight dropped from 60 mm with the New York University Impactor after laminectomy

Sacral nerve stimulation increased faecal output, shortened time to first faecal passage, improved faecal texture and colon histology, and raised 5-HT with upregulated 5-HT3AR and 5-HT4R mRNA and protein in colon and spinal cord.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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