Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats.
RatIschaemia-reperfusionCardiacWistarMalen = 30 rats subjected to cardiac ischaemia/reperfusion and 5 sh…Intravenous200 mg/kgGiven either during ischaemia or at the onset of reperfusion
Model: Cardiac ischaemia/reperfusion by 30 min ischaemia followed by 120 min reperfusion
Metformin did not alleviate impaired left ventricular ejection fraction, arrhythmias, infarct expansion, cardiac mitochondrial dysfunction or apoptosis, but attenuated brain mitochondrial dysfunction, apoptosis and Alzheimer's protein levels, with microglial morphology and dendritic spine density a…
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