Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway.
RatTBIUnspecifiedWistarMalen = Male Wistar rats divided into eight groups; numbers per gro…100 and 200 mg/kg
Model: Acute severe traumatic brain injury in rats
Metformin at 100 and 200 mg/kg attenuated brain oedema and blood-brain barrier disruption and improved vestibulomotor function with an increased p-AMPK/AMPK ratio, and these effects were abolished by the AMPK inhibitor compound C.
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