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PRECLINICAL PUBLICATION · 2020

Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 32608116 ↗2020Mixed findings

Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats.

RatSpinal cord injuryHemisection / partialMale and femaleInjection into the site of spinal cord transectionAcute delivery at the time of injury on postnatal day 3

Model: Thoracic hemi-section of the spinal cord in rat pups on postnatal day 3

HIF-activated pericytes increased vascular density in males but did not improve motor function in either sex, whereas non-HIF-activated pericytes improved motor recovery in both sexes (males 2.722 plus or minus 0.31-fold, females 3.824 plus or minus 0.58-fold score improvement, P less than 0.05) wi…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.